Regulation of inositol lipid kinases by Rho and Rac.
نویسندگان
چکیده
Rho and Rac small GTPases associate with type-I phosphatidylinositol 4-phosphate 5-kinase to regulate the production of phosphatidylinositol 4,5-bisphosphate. This lipid appears to mediate some of the effects of Rho and Rac on the actin cytoskeleton. The genes for several type-I phosphatidylinositol 4-phosphate 5-kinases have been cloned recently but it is not known which one interacts with Rho and/or Rac. Rho family GTPases also interact with phosphatidylinositol 3-kinase, though this kinase can be either upstream or downstream of the GTPases depending upon the system.
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ورودعنوان ژورنال:
- Current opinion in genetics & development
دوره 8 1 شماره
صفحات -
تاریخ انتشار 1998